Cover slip holder for bilateral and unilateral simulation of thrombogenesis in partly occluded blood vessels and use thereof
US5583043A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 18, 1994 |
| Grant date | Dec 10, 1996 |
| Priority date | — |
| Expiry date | Apr 18, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/808
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to a perfusion chamber 1, a mixing device 21, and a cover slip holder 6 for use together with the perfusion chamber 1. The bottom of the cover slip holder 6 is provided with cross-located grooves 11, 12, 13-1 for installing cover slips 14, 15, 16-1, and in which the cover slips 14, 15, 16-1 are positioned in comparison to each other in such a way that the cross-sectional area of the flow channel 4 is constricted unilaterally, for simulation of thrombogenesis in human blood vessels with stenosis. The bottom of the perfusion chamber 1, in the measure chamber 7, can also have an elevation into the flow channel 4 in the measure chamber 7 which together with the recessed cover slip holder bottom produces a bilateral constriction of the cross-sectional area of the measure chamber 7. A mixing device 21 is connected to the system upstream of the perfusion chamber 1 and produces homogeneous mixing of solutions added to the blood flow. The use of the perfusion chamber 1, the cover slip holder 6 and the mixing device 21 is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.