Birch pollen allergen P14 for diagnosis and therapy of allergic diseases

US5583046A · kind A · utility

Assignee

• Biomay Biotechnik Produktions Und Handelsgesellschaft m.b.H. · AT

Inventors

• Rudolf Valenta · Theresienfeld, AT
• Michael Duchene · Wien, AT
• Karin Pettenburger · Wien, AT
• Michael Breitenbach · Wien, AT
• Dietrich Kraft · Wien, AT
• Helmut Rumpold · Wien, AT
• Otto Scheiner · Perchtoldsdorf, AT

Key dates

• Filing date: Jun 6, 1992
• Grant date: Dec 10, 1996
• Expiry date: Jun 6, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides recombinant DNA molecules which code for proteins or polypeptides that exhibit the antigenicity of a P14 allergen of birch Betula verrucosa and other plants of the order Fagales, and for polypeptides comprising at least one epitope thereof, as well as nucleic acids which under stringent conditions hybridize with such DNA sequences or are derivable from such sequences by degeneracy of the genetic code. A method is provided that permits purification of P14 allergens or cross-reactive allergens by means of binding to poly(L-proline). In addition, methods are described for making the proteins and polypeptides coded by these DNA molecules and their use in the diagnosis or therapy of allergic diseases.