25-Carboxylic acid derivatives in the vitamin D series, process for their production, intermediate products for these processes, pharmaceutical preparations containing these derivatives as well as their use for the production of pharmaceutical agents

US5583125A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Andreas Steinmeyer · Berlin, DE
• G unter Neef · Berlin, DE
• Gerald Kirsch · Berlin, DE
• Katica Schwarz · Berlin, DE
• Ruth Thieroff-Ekerdt · Concord, US
• Herbert Wiesinger · Berlin, DE
• Martin Haberey · Berlin, DE

Key dates

• Filing date: Oct 6, 1993
• Grant date: Dec 10, 1996
• Expiry date: Oct 6, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New 25-carboxylic acid derivatives of general formula I, ##STR1## R.sup.19 and R.sup.19a each mean a hydrogen atom or together form an exocyclic methylene group, R.sup.21 and R.sup.21a independently of one another mean a hydrogen atom, a chlorine or fluorine atom, an alkyl group with 1 to 4 carbon atoms, together a methylene group, together with quaternary carbon atom 20 mean a 3-7 membered, saturated or unsaturated carboxylic ring, Y preferably means a derivatized carboxyl radical, and the other substituents have the meanings indicated in the description as well as process for their production, are described. The new compounds have vitamin D activity as well as proliferation-inhibiting and cell-differentiating effects and are suitable for the production of pharmaceutical agents.