Benzo-fused lactams promote release of growth hormone

US5583130A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Richard J. Bochis · East Brunswick Township, US
• Michael H. Fisher · Bound Brook, US
• Robert J. DeVita · Westfield, US
• William R. Schoen · Edison, US
• Matthew J. Wyvratt · Mountainside, US

Key dates

• Filing date: Sep 25, 1992
• Grant date: Dec 10, 1996
• Expiry date: Sep 25, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. The compounds are prepared by substitution of an amino-lactam with a substituted amide function. Growth promoting compositions containing such bezno-fused lactams as the active ingredient thereof are also disclosed. ##STR1## where L is ##STR2##