Malaria-specific DNA sequences, expression products thereof, and the use thereof

US5585268A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Bernhard Knapp · Marburg, DE
• Erika Hundt · Marburg, DE
• Burkhard Enders · Marburg, DE
• Hans K upper · Marburg, DE

Key dates

• Filing date: Sep 29, 1993
• Grant date: Dec 17, 1996
• Expiry date: Sep 29, 2013

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to malaria-specific nucleic acid sequences, to the expression products thereof, and to the use thereof. A combination of three of the expression proteins whose nucleic acid sequences were isolated by screening a lambda gt11 gene bank with a monospecific antiserum against the protective 41 kD antigen band from P. falciparum protects Aotus monkeys from a P. falciparum infection in model experiments.