Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US5585382A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1995 |
| Grant date | Dec 17, 1996 |
| Priority date | — |
| Expiry date | Feb 21, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09B57/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 are independently selected from the group H, C.sub.1 -C.sub.4 alkyl, OR.sup.4, N(R.sup.4).sub.2, NO.sub.2, CN, F, Cl, Br, I, Ph, and CF.sub.3, and NHC(O)R.sup.4 ; PA1 R.sup.4 is independently selected from the group H, C.sub.1 -C.sub.4 alkyl, Ph, and CH.sub.2 Ph; PA1 X.sup.1 and Y.sup.1, and X.sup.2 and Y.sup.2 when present, join together to form: PA2 a benzene ring substituted with 1-4 R.sup.3 ; PA2 a five membered heterocycle having 1-2N, NH, O or S atoms and substituted with 1-2 R.sup.3 ; PA2 a six membered heterocycle having 1-2N and substituted with 1-2 R.sup.3 ; or PA2 the group: ##STR2## wherein one of W or Z is C.dbd.O and the other is C.dbd.O, NH, S or O; or when X.sup.2 and Y.sup.2 are present and not joined together and when R.sup.2 is in the 4-position, then X.sup.2 and R.sup.2 may join together to form an ethylene bridge; PA1 are addressed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.