Linking reagents for nucleotide probes
US5585481A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1994 |
| Grant date | Dec 17, 1996 |
| Priority date | — |
| Expiry date | Jan 14, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/2408
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.