Method of producing optically active pyrrolidines with high enantiomeric purity

US5585500A · kind A · utility

Assignee

• Degussa AG · DE

Inventors

• Karlheinz Drauz · Alzenau, DE
• Matthias Kottenhahn · Alzenau, DE
• Michael Kraft · Blaustein, DE
• Michael Schwarm · Alzenau, DE

Key dates

• Filing date: Jul 17, 1995
• Grant date: Dec 17, 1996
• Expiry date: Jul 17, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of producing optically active pyrrolidines of the general formula ##STR1## in which R.sup.1 is hydrogen or OH, PA0 R.sup.2 is a benzyl group which can have one or more alkyl-, alkoxy- and/or halogen substituents on the aromatic, and PA0 * is and/or can be an asymmetric center, by reducing the corresponding, enantiomerically pure pyrrolidinediones using activated alkali boron hydride.