Diazine chelating agents for diagnostic imaging

US5587144A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Torsten Alm en · Nyköping, SE
• Arne Berg · Sandvika, NO
• Harald Dugstad · Oslo, NO
• Jo Klaveness · Oslo, NO
• Klaus D. Krautwurst · Kongsberg, NO
• Pal Rongved · Oslo, NO

Key dates

• Filing date: Jun 6, 1995
• Grant date: Dec 24, 1996
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Heterocyclic chelating agents and salts thereof of formula I: ##STR1## wherein X represents a bond, O or S, or a group CHR.sup.1 or NR.sup.3 ; each R.sup.1 represents H, a group OR.sup.3 or NR.sup.3 R.sup.3, or an alkyl or alkoxyalkyl group optionally substituted by a hydroxyl group or by a group NR.sup.3 R.sup.3 or CON.sup.3 R.sup.3 ; PA1 each R.sup.2 represents H, or an alkyl or alkoxy group optionally substituted by a hydroxyl or alkoxy group; PA1 each R.sup.3 represents H, an optionally hydroxylated alkyl group or a group CH.sub.2 Y; PA1 Y represents a group COZ, CON(OH)R.sup.4, POZ.sub.2 or SO.sub.2 Z, PA1 Z represents a group OR.sup.4, NR.sup.4 R.sup.4 or ##STR2## where each R.sup.11 is H, a hydroxyl group or an optionally hydroxylated alkyl group, s is 0, 1 or 2, and W is CHR.sup.11, NR.sup.11 or an oxygen atom; and PA1 each R.sup.4 represents H, or an optionally mono- or poly-hydroxylated alkyl, alkoxyalkyl or polyalkoxyalkyl group; with the provisos that where s is 0 then W is CHR.sup.11 and that where X represents a bond or CHR.sup.1, at least one group R.sup.1 or R.sup.2 represents other than H or an unsubstituted alkyl group, A process for preparing these agents and met…