Process for the preparation of L-phosphinothricin using transaminases of different specificities in a linked process

US5587319A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Johann Then · Hofheim, DE
• Werner Aretz · Königstein, DE
• Klaus Sauber · Schwalbach, DE

Key dates

• Filing date: Jul 8, 1994
• Grant date: Dec 24, 1996
• Expiry date: Jul 8, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/006
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

L-2-Amino-4-methylphosphinobutyric acid can be prepared by a racemate resolution in the presence of D-aminoacid and L-aminoacid transaminases by reaction with .alpha.-keto acids and amino-group donors. In particular, transaminases from Bacillus licheniformis and from Escherichia coli are used.