Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity

US5587384A · kind A · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• The United States of America · US

Inventors

• Jie Zhang · Beijing, CN
• Valina L. Dawson · Baltimore, US
• Ted M. Dawson · Baltimore, US
• Solomon H. Snyder · Baltimore, US

Key dates

• Filing date: Feb 4, 1994
• Grant date: Dec 24, 1996
• Expiry date: Feb 4, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/165
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.