Method of ameliorating cellulite by disrupting the barrier function of the stratum corneum
US5587396A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 26, 1994 |
| Grant date | Dec 24, 1996 |
| Priority date | — |
| Expiry date | Aug 26, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New topically applied treatments for cellulite are shown by comparative data to effect structural improvements in cellulite-afflicted thigh area tissues including skin-thickening, thigh-firming and thigh-reduction. The disclosed treatments disrupt the skin's water barrier and elevate trans-epidermal water loss (TEWL) for extended periods of weeks or months and include methods of mechanical or solvent action, for example, tape stripping, or acetone washes. Preferred treatments use creams with active ingredients such as lactic acid to elevate TEWL, a retinoid, preferably vitamin A palmitate to disrupt barrier rebuilding and prolong elevation of TEWL levels, and a cerebroside to inhibit lipid synthesis and intensify the TEWL elevation. Diuretics, for immediate esthetic improvements, anti-irritants and anti-oxidants for irritation control are optional ingredients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.