4-substituted anthracyclinones and anthracycline glycosides and the process for preparing them
US5587495A · kind A · utility
4Cited by
1References
16Claims
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Key dates
| Filing date | Apr 25, 1991 |
| Grant date | Dec 24, 1996 |
| Priority date | — |
| Expiry date | Apr 25, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
4-substituted anthracyclinones of formula (I): ##STR1## wherein R represents a straight or branched alkyl, alkenyl or alkynyl group of up to 16 carbon atoms optionally substituted by (a) an aryl group which is unsubstituted or substituted by an inert group such as an alkyl, alkoxy or nitro group; (b) an alkoxy group; (c) a trialkylsilyl group, (d) an ester group or (e) an amido group, are intermediates in the preparation of antitumor anthracycline glycosides of formula (IX): ##STR2## wherein R is as defined above and R.sub.1 is a hydrogen atom or a hydroxy group, and pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.