Triterpene derivatives and endothelin-receptor antagonists containing the same
US5587505A · kind A · utility
5Cited by
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2Claims
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Key dates
| Filing date | Jul 26, 1995 |
| Grant date | Dec 24, 1996 |
| Priority date | — |
| Expiry date | Jul 26, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J63/008
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Triterpene derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydrogen or metabolic ester residue; and R.sup.2 is hydrogen or --R.sup.3 -R.sup.4 wherein R.sup.3 is --SO.sub.3 --, --CH.sub.2 COO--, --COCOO--, or --COR.sup.5 COO-- (R.sup.5 is lower alkylene or lower alkenylene), and R.sup.4 is hydrogen or metabolic ester residue or a pharmaceutically acceptable salt thereof, which have anti-endothelin activities and are useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.