Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein
US5589385A · kind A · utility
8Cited by
7References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 22, 1993 |
| Grant date | Dec 31, 1996 |
| Priority date | — |
| Expiry date | Sep 22, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/18
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.