Apparatus for causing medicinal products to penetrate into red blood cells
US5589389A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 3, 1994 |
| Grant date | Dec 31, 1996 |
| Priority date | — |
| Expiry date | Aug 3, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2205/366
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An apparatus for incorporating one or more biologically active substances into red blood corpuscles (erythrocytes) by lysis and resealing technique comprises a washing unit, a lysis unit and a resealing unit. The washing unit obtains a suspension of erythrocytes from complete or incomplete blood. The lysis unit cools the erythrocyte suspension to a temperature below 10.degree. C. and maintains this temperature while the suspension is processed through a dialysis unit and subsequently exposed to the active substance. The treated erythrocyte suspension is held in a retardation pouch for a predetermined time and thereafter fed to the resealing unit, which heats the treated suspension to a temperature higher than 20.degree. C. and maintains this temperature while the treated suspension is exposed to the resealing product. The suspension exposed to the resealing product is collected in a collecting pouch for a predetermine period before it is discharged to the washing unit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.