Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis

US5589452A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• John L. Krstenansky · Palo Alto, US
• John J. Nestor · Cupertino, US
• Teresa H. Ho · Los Altos, US
• Brian H. Vickery · Cupertino, US
• Chinh T. Bach · San Jose, US

Key dates

• Filing date: Jul 14, 1992
• Grant date: Dec 31, 1996
• Expiry date: Jul 14, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: EQU Haa(Laa Laa Haa Haa).sub.2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.