Liquid preparation of antithrombin-III and stabilizing method therefor
US5589516A · kind A · utility
4Cited by
25References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 5, 1994 |
| Grant date | Dec 31, 1996 |
| Priority date | — |
| Expiry date | Dec 5, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A liquid preparation of antithrombin-III (AT-III), comprising an AT-III and an organic acid, a salt thereof, a sugar sulfate or a surfactant as a stabilizer, and a liquid preparation of AT-III, having a pH of 9-10. The preparation of the present invention is stable after long-term preservation and poses no clinical problems in terms of pharmacological effects and safety. The preparation is more advantageous than lyophilized preparations in that it does not require dissolution in injectable distilled water and can be used easily. Accordingly, the preparation is clinically very useful.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.