Nucleosides attached to a solid support through a 3'-silyl linkage and their use in oligonucleotide synthesis
US5589586A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 24, 1992 |
| Grant date | Dec 31, 1996 |
| Priority date | — |
| Expiry date | Jul 24, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Support system for the synthesis of oligonucleotides wherein the first nucleoside is bound to the support via a silylether linkage, especially of the formula ##STR1## wherein B is a nucleoside or deoxynucleoside base. PA1 R.sub.1 is a protecting group. PA1 R.sub.2 is --H, --OH, or --OR.sub.5, in which R.sub.5 is a protecting group. PA1 R.sub.3, R.sub.4 and X each represent alkyl, aryl, cycloalkyl, alkenyl, aralkyl, cycloalkylalkyl, alkyloxy, aryloxy, cycloalkyloxy, alkenyloxy, aralkyloxy. PA1 S is a solid support, whereby not more than one of R.sub.3, R.sub.4 and X represent alkyloxy, aryloxy, cycloalkyloxy, alkenyloxy, aralkyloxy or cycloalkylalkyloxy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.