Process for the preparation of cephem prodrug esters

US5589594A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Elisabeth Defossa · Idstein, DE
• Gerd Fischer · Limburg, DE
• Uwe Gerlach · Hattersheim, DE
• Rolf Horlein · Frankfurt am Main, DE
• Norbert Krass · Frankfurt am Main, DE
• Rudolf Lattrell · Königstein, DE
• Ulrich Stache
• Theodor Wollmann · Hofheim, DE

Key dates

• Filing date: Dec 30, 1993
• Grant date: Dec 31, 1996
• Expiry date: Dec 30, 2013

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the preparation of cephem prodrug esters of the formula: ##STR1## in which R.sup.1 is C.sub.1 -C.sub.5 -alkanoyloxy-C.sub.1 -C.sub.3 -alkyl or C.sub.1 -C.sub.5 -alkoxycarbonyloxy-C.sub.1 -C.sub.3 -alkyl and X is an inorganic or organic anion, and in which the hydroxyimino group is present in the syn-form.