Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof
US5591430A · kind A · utility
18Cited by
4References
6Claims
0Family size
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Key dates
| Filing date | Jun 17, 1994 |
| Grant date | Jan 7, 1997 |
| Priority date | — |
| Expiry date | Jun 17, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/865
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.