Process for preparing aprotinin and aprotinin analogs in yeast cells
US5591603A · kind A · utility
4Cited by
5References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 23, 1993 |
| Grant date | Jan 7, 1997 |
| Priority date | — |
| Expiry date | Jun 23, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods for producing aprotinin and analogs thereof in yeast, synthetic genes encoding such products, expression vectors and transformed yeast cells. The invention further relates to aprotinin analogs, particularly analogs with increased specific inhibitory activity and/or reduced nephrotoxicity compared to native aprotinin, as well as compositions comprising such analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.