Organic nitrates, processes for their preparation and their use in the treatment of cardiovascular diseases

US5591758A · kind A · utility

Assignee

• Laboratories Hoechst S/A · FR

Inventors

• Jean Pierre Nallet · Montanay, FR
• Jacques Dreux · Val-de-Reuil, FR
• Alain Berdeaux · Créteil, FR
• Vincent Richard · Paris, FR
• Piero Martorana · Bad Homburg vor der Höhe, DE
• Helmut Bohn · Schöneck, DE

Key dates

• Filing date: May 4, 1993
• Grant date: Jan 7, 1997
• Expiry date: May 4, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Organic nitrates, processes for their preparation and their use in the treatment of vascular diseases and in particular in the treatment of angina. The said nitrates correspond to the following formula I: EQU R--CO--(A).sub.n --Y--B (I) in which: R represents, in particular, a sulphur-containing radical and a sulphur-containing amino acid residue; A represents, in particular, a CH.sub.2 group or a substituted amino acid; n is 0 or 1 or greater than 1; Y represents an oxygen atom or an NH group and B represents, in particular, a 1,4:3,6-dianhydro hexitol mononitrate radical, an itol nitrate radical or an inositol radical. The said organic nitrates are prepared by reacting: PA1 I. either a thio acid of the type R--COOH, in which R has the same meaning as above, with a derivative of formula II: (A).sub.n --Y--B, in which A, Y, B and n have the same meaning as above, PA1 II. or a derivative of formula III: R--CO--(A).sub.n, in which R, A and n have the same meaning as above, with a derivative of formula Y--B, in which Y and B have the same meaning as above, in an appropriate solvent and under non-epimerising conditions.