Suppression of proliferative response and induction of tolerance with polymorphic class II MHC allopeptides
US5593698A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 5, 1993 |
| Grant date | Jan 14, 1997 |
| Priority date | — |
| Expiry date | Mar 5, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described are methods for: (a) suppressing the ability of T-cells from a mammal to proliferate in response to stimulation by nonself mammalian tissue; and (b) suppressing immune response which leads to allograft rejection in a mammal receiving an allograft from a donor mammal. The methods involve orally administering to the mammal to be thus treated a composition comprising at least one of: (i) a major histocompatibility complex Class II antigen from a second nonself mammal or from tissue of a mammal syngeneic to said nonself mammal; (ii) at least one synthetic peptide corresponding to a T-cell suppressive fragment of said Class II antigen, said composition being administered in an amount effective to suppress said proliferation. The foregoing compositions are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.