Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens

US5593823A · kind A · utility

Assignee

• Cerus Corporation · US

Inventors

• Susan Wollowitz · Walnut Creek, US
• Stephen T. Isaacs · Orinda, US
• Henry Rapoport · Berkeley, US
• Hans Peter Spielmann · Lexington, US
• Aileen Nerio · Fremont, US

Key dates

• Filing date: Nov 14, 1994
• Grant date: Jan 14, 1997
• Expiry date: Nov 14, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.