Binding of immune complexes by modified forms of C-reactive protein
US5593897A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 6, 1994 |
| Grant date | Jan 14, 1997 |
| Priority date | — |
| Expiry date | Jul 6, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/824
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with modified forms of C-reactive protein. The method may be employed for diagnostic and therapeutic purposes and to deplete fluids of aggregated immunoglobulin or immune complexes. Further, a method of reducing the levels of immune complexes in a mammal comprising administering modified-CRP to the mammal, and a method of binding immunoglobulins comprising contacting them with modified C-reactive protein. Also, a method of binding aggregated immunoglobulin or immune complexes comprising contacting them with antibody to neo-CRP, and a method of modifying C-reactive protein. Finally, a test kit for detecting or quantitating immune complexes and a device for removing aggregated immunoglobulin or immune complexes from fluids are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.