Localized oligonucleotide therapy
US5593974A · kind A · utility
96Cited by
5References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 6, 1995 |
| Grant date | Jan 14, 1997 |
| Priority date | — |
| Expiry date | Jan 6, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/315
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a method for localized application of antisense oligonucleotides, which has been found to be effective in inhibiting expression and translation of a variety of genes. The method utilizes antisense oligonucleotides which are specific for the mRNA transcribed from the gene of interest. The antisense oligonucleotides are applied directly to the desired locus of the cells to be treated, where they hybridize with the mRNA and inhibit expression of the gene. Devices for localized antisense application and methods for making them also are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.