Use of quinoline-3-carboxamide compounds for treatment of diabetes

US5594005A · kind A · utility

Assignee

• Pharmacia AB · SE

Inventors

• Shimon Slavin · Jerusalem, IL
• Lola Weiss · Jerusalem, IL
• David Gross · Mevaseret Tsiyon, IL

Key dates

• Filing date: Dec 23, 1994
• Grant date: Jan 14, 1997
• Expiry date: Dec 23, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Quinoline-3-carboxamide compounds of formula (I) are effective in preventing, treating or ameliorating Type I diabetes. ##STR1## wherein ----- represents two conjugated double bonds between the atoms comprised by the dashed line, X.sub.1 and X.sub.2 are independently selected from an oxygen atom or NH.sup.9, H.sup.1-9 independently represent a hydrogen atom or a substituent, wherein H.sup.7 and H.sup.8 are attached to different atoms selected from X.sub.1, X.sub.2 and the ring nitrogen atom of the quinoline ring. In particular, X.sub.1 and X.sub.2 being bound by a single bond to the ring when H.sup.7 or H.sup.8 is bonded thereto and by a double bond when H.sup.7 or H.sup.8 is not bonded thereto.