Liposomal compositions for enhanced retention of bioactive agents
US5595756A · kind A · utility
600Cited by
3References
10Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Dec 22, 1993 |
| Grant date | Jan 21, 1997 |
| Priority date | — |
| Expiry date | Dec 22, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1272
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Liposomal compositions encapsulating bioactive agents and having improved circulation longevity of the agents are disclosed. Such liposomes combine a low pH of the solution in which a bioactive agent is entrapped and a sugar-modified lipid or an amine-bearing lipid, the combination of which enhances the retention of the encapsulated bioactive agent and thereby promotes circulation longevity. The present invention also discloses methods of making and using such compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.