Patent · US Expired

Piezoelectric device for detection of polynucleotide hybridization

US5595908A · kind A · utility

88Cited by
7References
9Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 11, 1989
Grant dateJan 21, 1997
Priority date—
Expiry dateAug 11, 2009

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2291/0257
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

A system for detecting polynucleotide hybridization is disclosed. A polynucleotide is immobilized on a surface of a piezoelectric crystal. The resonance frequency of the piezoelectric crystal is measured through means for determining the resonant frequency of a piezoelectric crystal. A separate source of polynucleotide is exposed to the polynucleotide-coated piezoelectric crystal for a sufficient length of time and under conditions suitable for hybridization. The resonance frequency of the crystal is then again measured, and the difference between the resonance frequency before and after the incubation period will indicate the extent of hybridization.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.