Amino acid derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds

US5596000A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Franz Esser · Ingelheim am Rhein, DE
• Gerd Schnorrenberg · Ingelheim am Rhein, DE
• Horst Dollinger · Schemmerhofen, DE
• Birgit Jung · Laupheim, DE
• Erich Burger

Key dates

• Filing date: Sep 2, 1993
• Grant date: Jan 21, 1997
• Expiry date: Sep 2, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new amino acid derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, wherein group R.sup.5 is ##STR2## and R.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, Z, t and u have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.