Amino bi- and tri-carbocyclic alkane bis-aryl squalene synthase inhibitors
US5596020A · kind A · utility
18Cited by
1References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 7, 1994 |
| Grant date | Jan 21, 1997 |
| Priority date | — |
| Expiry date | Dec 7, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D263/57
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.