Process for the preparation of N-(2-sulfatoethyl)-piperazine in high purity

US5596099A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Michael Meier · Frankfurt am Main, DE
• Heinz-Georg Kautz · Nierstein, DE

Key dates

• Filing date: Mar 15, 1995
• Grant date: Jan 21, 1997
• Expiry date: Mar 15, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/088
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of N-(2-sulfatoethyl)-piperazine in high purity, which comprises reacting N-(2-hydroxyethyl)piperazine in a mixture of highly--or relatively highly--concentrated sulfuric acid and oleum or chlorosulfonic acid at temperatures of from about 80.degree. to about 250.degree. C., transferring the resulting sulfonation mixture to a water-miscible aliphatic alcohol, isolating the N-(2-sulfatoethyl)piperazine sulfate formed, treating the N-(2-sulfatoethyl)piperazine sulfate, still moist with alcohol, at temperatures of from about 35.degree. to about 90.degree. C. with a basic compound in a mixture of a (C.sub.1 -C.sub.2)-alkanol and water, separating off the precipitated sulfate of the basic compound employed, and isolating the N-(2-sulfatoethyl)piperazine formed, by the addition of (C.sub.1 -C.sub.2)-alkanol.