Oral dosage form of biologically active proteins
US5597562A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 15, 1993 |
| Grant date | Jan 28, 1997 |
| Priority date | — |
| Expiry date | Dec 15, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P7/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An oral dosage form comprising: (a) granulocyte colony stimulating factor or erythropoietin; (b) surfactant(s); (c) fatty acid(s); and (d) enteric material. The oral drug preparations provided by the present invention avoid inactivation of the principal ingredient during the process of pharmaceutical manufacturing and display enhanced absorption of the ingredient from the intestinal tract, particularly as a result of the addition of fatty acid(s) to the drug composition. As such, oral dosage forms of the present invention can allow for dosage reductions, facilitate accurate dose control, and increase the practical usefulness of the bioactive proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.