Hormone response element compositions and assay
US5597693A · kind A · utility
83Cited by
3References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 16, 1990 |
| Grant date | Jan 28, 1997 |
| Priority date | — |
| Expiry date | Mar 16, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/721
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention discloses steroid/thyroid hormone receptor DNA binding domain compositions that determine target gene specificity. The invention further discloses methods converting the target gene specificity of one receptor into the target gene specificity of another. Still further the invention discloses novel assays for identifying ligands for orphan hormone receptors. These assays are especially useful since they avoid the necessity of constructing chimeric genes and proteins in order to search for ligands that can activate a putative receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.