Patent · US Expired

Bradykinin peptides with modifications at the N terminus

US5597803A · kind A · utility

4Cited by

3References

3Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Gerhard Breipohl · Scheinfeld, DE
Stephan Henke · Bad Soden am Taunus, DE
Jochen Knolle · Kriftel, DE
Bernward Scholkens · Kelkheim, DE
Hans G. Alpermann · Bocholt, DE
Hermann Gerhards · Hofheim, DE
Klaus Wirth · Frankfurt am Main, DE

Key dates

Filing date	Jan 17, 1995
Grant date	Jan 28, 1997
Priority date	—
Expiry date	Jan 17, 2015

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Peptides of the formula I EQU Z-P-A-B-C-E-F-K-(D)Q-G-M-F'-I (I) and the physiologically tolerated salts thereof, are described. They have an excellent bradykinin-antagonistic action. They are obtained by reacting reacting a fragment with a C-terminal free carboxyl group or its activated derivative with a corresponding fragment with an N-terminal free amino group or assembling the peptide stepwise, where appropriate eliminating in the compound obtained in this way one or more protective groups introduced temporarily to protect other functionalities, and where appropriate converting the compounds of the formula I obtained in this way into the physiologically tolerated salt thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.