2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

US5597841A · kind A · utility

Assignee

• Sterling Winthrop Inc. · US

Inventors

• Richard P. Dunlap · Penfield, US
• Neil Warren Boaz · Kingsport, US
• Albert J. Mura · Rochester, US
• Virendra Kumar · Paoli, US
• Chakrapani Subramanyam · South Glastonbury, US
• Ranjit C. Desai · Colonie, US
• Dennis J. Hlasta · Doylestown, US
• Manohar T. Saindane · Monmouth Junction, US
• Malcolm R. Bell · East Greenbush, US
• John J. Court · Littleton, US
• Robert P. Farrell · Thousand Oaks, US

Key dates

• Filing date: May 19, 1995
• Grant date: Jan 28, 1997
• Expiry date: May 19, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6541
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an acid-acceptor.