Triarylmethyl radicals and the use of inert carbon free radicals in MRI

US5599522A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Mikkel J.o slashed.rgensen · Taastrup, DK
• Frode Rise · Vinstra, NO
• Sven Andersson · Malmö, SE
• Torsten Almen · Malmö, SE
• Klaes Golman · Hørsholm, DK

Key dates

• Filing date: Sep 2, 1992
• Grant date: Feb 4, 1997
• Expiry date: Sep 2, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A radical compound of formula Ia EQU .C(Ar.sup.12).sub.3 (Ia) wherein: PA1 each Ar.sup.12, which may be the same or different, represents a 6-membered carbocyclic, at least one group Ar.sup.12 being a group Ar.sup.1 ; PA1 each group Ar.sup.1 represents a 6-membered ring optionally substituted at the or any ortho carbon by a group R.sup.1, R.sup.2, R.sup.3 or R.sup.4, at the or any meta carbon by a group R.sup.2 or R.sup.3, and at any para carbon by a group R.sup.1, R.sup.2, R.sup.3 or R.sup.4, PA1 with the proviso that no more than two ring carbons are unsubstituted; PA1 each of R.sup.1, R.sup.2, R.sup.3 or R.sup.4, which may be the same or different, independently represents a group of formula --M, --XM, --XAr.sup.2 or --Ar.sup.2 ; PA1 M represents a water solubilizing group, each group X, which may be the same or different, represents an oxygen or sulphur atom or a NH or CH.sub.2 group.