Thiazolidinediones and drugs containing them

US5599826A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Alfred Mertens · Schriesheim, DE
• Hans-Peter Wolff · Mannheim, DE
• Peter C. Freund · Ketsch, DE

Key dates

• Filing date: Nov 21, 1995
• Grant date: Feb 4, 1997
• Expiry date: Nov 21, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## in which A denotes a carbocyclic ring with 5 or 6 carbon atoms or a heterocyclic ring with a maximum of 4 heteroatoms in which the heteroatoms can be the same or different and denote oxygen, nitrogen or sulphur and the heterocycles can if desired carry an oxygen atom on one or several nitrogen atoms, B denotes --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N--, O or S, W denotes CH.sub.2, O, CH(OH), CO or --CH.dbd.CH--, X denotes S, O or NR.sup.2 in which the residue R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl, Y is CH or N, R denotes naphthyl, pyridyl, furyl, thienyl or phenyl which if desired is mono- or disubstituted with C.sub.1 -C.sub.3 alkyl, CF.sub.3, C.sub.1 -C.sub.3 alkoxy, F, Cl or bromine, R.sup.1 denotes hydrogen or C.sub.1 -C.sub.6 alkyl and n equals 1-3 as well as their tautomers, enantiomers, diastereomers and physiologically tolerated salts, processes for their production as well as pharmaceutical agents that contain these compounds for the treatment of diabetes.