Vaccines for nontypable Haemophilus influenzae
US5601831A · kind A · utility
22Cited by
6References
33Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1990 |
| Grant date | Feb 11, 1997 |
| Priority date | — |
| Expiry date | Mar 9, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Protein "e" of H. influenzae, a lipoprotein of approximately 28,000 daltons, has been purified and sequenced. Protein "e" and peptides or proteins having a shared epitope, can be used to vaccinate against non-typable (and typable) H. influenzae and to prevent otitis media caused by H. influenzae. For this purpose, protein "e" or derivatives thereof can be produced in native, synthetic or recombinant forms and can be administered alone or in conjunction with other antigens of H. influenzae. Protein "e" can also be used in multivalent vaccines designed for H. influenzae and one or more other infectious organisms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.