Apparatus and method for detecting coagulation in blood samples
US5601995A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 3, 1995 |
| Grant date | Feb 11, 1997 |
| Priority date | — |
| Expiry date | Mar 3, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/86
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The method and apparatus are useful for determining a propensity of a blood sample to change from a liquid state to a coagulated state and additionally for measuring the propensity of a coagulated blood sample to lyse. The method includes providing a porous sheet, at least one surface of which contacts an impervious layer; applying the blood sample to an exposed surface of the porous sheet so that the blood sample spreads through a part of the porous sheet; and after the applying of the blood sample to the porous sheet, measuring at least one of a spreading extent and a spreading rate of the blood sample in the porous sheet by measuring either an optical property, an electrical conductivity across the porous sheet, an electrical potential across the porous sheet and an electrical resistance of the porous sheet to determine the propensity of the blood sample to coagulate. The porous sheet can also be impregnated with a clotting agent or a lytic agent to affect the clotting or lysing of the blood sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.