Dominant negative chimeras of the steroid/thyroid superfamily of receptors

US5602009A · kind A · utility

Assignee

• Salk Institute for Biological Studies · US

Inventors

• Ronald M. Evans · Village of La Jolla, US
• Stanley M. Hollenberg · San Diego, US
• Anthony E. Oro · Stanford, US
• Klaus Damm · Meitingen, DE
• Richard A. Heyman · Encinitas, US

Key dates

• Filing date: May 10, 1993
• Grant date: Feb 11, 1997
• Expiry date: May 10, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed are novel trans-repressing analog receptors wherein the ligand-binding domain(s) are modified versus wild type receptor, such novel receptors having repressed trans-activation transcription activation properties. Also disclosed are recombinant methods and means for preparing such receptors and assays using such receptors.