2-thiosubstituted carbapenems

US5602118A · kind A · utility

Assignee

• American Cyanamid Company · US

Inventors

• Yang-I Lin · Nanuet, US
• Panayota Bitha · Pomona, US
• Subas Sakya · Shanghai, CN
• Timothy W. Strohmeyer · Demarest, US
• Karen Bush · Kingston, US
• Carl Bernard Ziegler · East Lyme, US
• Gregg Feigelson · Monsey, US

Key dates

• Filing date: Jan 26, 1994
• Grant date: Feb 11, 1997
• Expiry date: Jan 26, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/582
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.