Receptor of the minor human rhinovirus receptor group
US5603932A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 23, 1996 |
| Grant date | Feb 18, 1997 |
| Priority date | — |
| Expiry date | Apr 23, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A substantially pure receptor with binding activity for rhinoviruses of the minor human receptor group is disclosed, which has the following characteristics: PA0 (a) a molecular weight of 120 kD on a polyacrylamide gel in the presence of SDS; PA0 (b) a sedimentation constant, determined by sucrose gradient centrifugation in the presence of detergents, corresponding to about 28.4 S; PA0 (c) is bound by Lens culinaris lectin; PA0 (d) is not bound by heparin-sepharose; PA0 (e) is bound irreversibly to an anion exchanger; PA0 (f) has binding activity which is insensitive to neuraminidase; PA0 (g) consists of sub-units connected by intermolecular disulfide bridges; PA0 (h) shows no binding activity to rhinoviruses in the presence of EDTA; and PA0 (i) has a binding activity to rhinoviruses which is only slightly influenced by iodoacetamide. A receptor subunit of the above-described receptor, produced by complete reduction of said receptor, is also disclosed. Multimeric forms of the above-described receptor, obtained by controlled oxidation of the monomeric receptor, are also disclosed. Methods of providing protection against infection by rhinoviruses of the minor receptor group with the …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.