Method and device for providing nicotine replacement therapy transdermally/transbuccally

US5603947A · kind A · utility

Assignee

• Cygnus Terapeutic Systems · US

Inventors

• Ooi Wong · Fremont, US
• Kathleen Cogan Farinas · Menlo Park, US
• Gary W. Cleary · San Mateo, US
• Chia-Ming Chiang · Foster City, US
• Jun Xia · Hefei, CN

Key dates

• Filing date: Jul 21, 1994
• Grant date: Feb 18, 1997
• Expiry date: Jul 21, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/465
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A skin or buccal patch for providing nicotine replacement therapy which comprises a matrix type laminated composite in which the matrix is composed of a mixture of nicotine in a polymer wherein the amount of nicotine in the matrix, diffusion coefficient of nicotine in the matrix and the thickness of matrix are such that the release of nicotine is: (1) controlled by the patch; (2) rapid and at a relatively high flux over the prescribed wearing time of patch; and (3) such that a substantial proportion of the nicotine initially in the patch has been released at the end of the prescribed wearing time.