Methods of screening for .beta.-amyloid peptide production inhibitors
US5604102A · kind A · utility
83Cited by
4References
19Claims
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Assignee
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Key dates
| Filing date | Oct 27, 1993 |
| Grant date | Feb 18, 1997 |
| Priority date | — |
| Expiry date | Oct 27, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Processing of .beta.-amyloid precursor protein (.beta.APP) is monitored by detecting the secretion of a soluble amino-terminal fragment or .beta.APP (ATF-.beta.APP) resulting from cleavage of .beta.APP at the amino-terminus of .beta.-amyloid peptide. Secretion of ATF-.beta.APP in animal models may be monitored to identify inhibitors of .beta.-amyloid production. The ATF-.beta.APP may be detected using antibodies and other specific binding substances which recognize a carboxy terminal residue on the fragment. Animals expressing the Swedish mutation of .beta.APP are described which produce abundant amounts of ATF-.beta.APP.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.