Method for exposing Group A streptococcal antigens and an improved diagnostic test for the identification of Group A streptococci
US5604109A · kind A · utility
46Cited by
6References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 13, 1994 |
| Grant date | Feb 18, 1997 |
| Priority date | — |
| Expiry date | Sep 13, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/808
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to the rapid detection of Group A streptococci in clinical specimens, through the enzymatic digestion by a semi-purified Group C streptococcal phage associated lysin enzyme and the identification of the released antigens, through the reaction of a labelled ligand and its respective antigen or receptor. The labelled ligand can be included during the digestion of the bacteria, enabling the total assay time to be less than five minutes. The lysin enzyme is stabilized and can be lyophilized for in situ reconstitution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.