Somatic mutations in neurofibromatosis type 1 gene in human tumors
US5605799A · kind A · utility
5Cited by
1References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 28, 1995 |
| Grant date | Feb 25, 1997 |
| Priority date | — |
| Expiry date | Mar 28, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/106
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to somatic mutations of the NF1 gene which are found in human tumors. In addition, the present invention is directed to methods of screening humans to determine those having somatic mutations in the NF1 gene in tumors. Finally, the invention is directed to a method of treating a human having a tumor with a somatic mutation in the NF1 gene by restoring natural regulation of ras proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.