Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein
US5605811A · kind A · utility
98Cited by
8References
7Claims
0Family size
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Key dates
| Filing date | May 12, 1995 |
| Grant date | Feb 25, 1997 |
| Priority date | — |
| Expiry date | May 12, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides methods for identifying beta amyloid production inhibitors, wherein cells are cultured under conditions which result in secretion of a soluble fragment of beta amyloid precursor protein. The amino acid sequence of the fragment extends from the amino terminus of beta APP to the amino terminus of the beta amyloid peptide. The cultured cells are exposed to test compounds which cause a change in the secreted amount of the soluble fragment of beta APP which is determined.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.