3,5-Disubstituted tetrahydrofuran-2-ones
US5606078A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 4, 1995 |
| Grant date | Feb 25, 1997 |
| Priority date | — |
| Expiry date | Apr 4, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula I ##STR1## wherein R.sub.1 is free or esterified carboxy, hydroxymethyl or formyl, PA1 R.sub.2 and R.sub.4 are each independently of the other aliphatic, cycloaliphatic-aliphatic, araliphatic or heteroarylaliphatic radicals and PA1 R.sub.3 is azido, or amino that is aliphatically or araliphatically substituted and/or protected by an amino-protecting group, PA1 and the salts thereof, are valuable intermediates in the preparation of medicinal active ingredients, for example of compounds of formula II ##STR2## wherein R.sub.A is an aromatic or heteroaromatic radical, PA1 R.sub.2 and R.sub.4 are each independently of the other aliphatic, cycloaliphatic, cycloaliphaticaliphatic or araliphatic radicals, PA1 R.sub.3 is unsubstituted or N-mono- or N,N-di-lower alkylated or N-lower alkanoylated amino, and PA1 R.sub.B is an aliphatically, cycloaliphatically or heteroaromatically-aliphatically substituted amino group, PA1 and the salts thereof, which can be used, for example, as antihypertensives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.